In-vitro renal epithelial cell infection reveals a viral kidney tropism as a potential mechanism for acute renal failure during Middle East Respiratory Syndrome (MERS) Coronavirus infection
Identifieur interne : 002075 ( Main/Exploration ); précédent : 002074; suivant : 002076In-vitro renal epithelial cell infection reveals a viral kidney tropism as a potential mechanism for acute renal failure during Middle East Respiratory Syndrome (MERS) Coronavirus infection
Auteurs : Isabella Eckerle [Allemagne] ; Marcel A. Müller [Allemagne] ; Stephan Kallies [Allemagne] ; Daniel N. Gotthardt [Allemagne] ; Christian Drosten [Allemagne]Source :
- Virology Journal [ 1743-422X ] ; 2013.
Descripteurs français
- KwdFr :
- MESH :
- physiologie : Coronavirus.
- virologie : Atteinte rénale aigüe, Cellules épithéliales.
- Adulte, Adulte d'âge moyen, Cellules cultivées, Humains, Infections à coronavirus, Mâle, Sujet âgé, Tropisme viral.
English descriptors
- KwdEn :
- MESH :
- complications : Coronavirus Infections.
- physiology : Coronavirus.
- virology : Acute Kidney Injury, Epithelial Cells.
- Adult, Aged, Cells, Cultured, Humans, Male, Middle Aged, Viral Tropism.
Abstract
The Middle East Respiratory Syndrome Coronavirus (MERS-CoV) causes symptoms similar to Severe Acute Respiratory Syndrome Coronavirus (SARS-CoV), yet involving an additional component of acute renal failure (ARF) according to several published case reports. Impairment of the kidney is not typically seen in Coronavirus infections. The role of kidney infection in MERS is not understood.
A systematic review of communicated and peer-reviewed case reports revealed differences in descriptions of kidney involvement in MERS versus SARS patients. In particular, ARF in MERS patients occurred considerably earlier after a median time to onset of 11 days (SD ±2,0 days) as opposed to 20 days for SARS, according to the literature.
Epidemiological studies should analyze kidney impairment and its characteristics in MERS-CoV. Virus replication in the kidney with potential shedding in urine might constitute a way of transmission, and could explain untraceable transmission chains leading to new cases. Individual patients might benefit from early induction of renoprotective treatment.
The online version of this article (doi:10.1186/1743-422X-10-359) contains supplementary material, which is available to authorized users.
Url:
DOI: 10.1186/1743-422X-10-359
PubMed: 24364985
PubMed Central: 3878046
Affiliations:
- Allemagne
- Bade-Wurtemberg, District de Cologne, District de Karlsruhe, Rhénanie-du-Nord-Westphalie
- Bonn, Heidelberg
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Le document en format XML
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Gotthardt</name><affiliation wicri:level="3"><nlm:aff id="Aff2"><institution-wrap><institution-id institution-id-type="GRID">grid.5253.1</institution-id><institution-id institution-id-type="ISNI">0000000103284908</institution-id><institution>Department of Internal Medicine IV,</institution><institution>University Hospital Heidelberg,</institution></institution-wrap>Im Neuenheimer Feld 410, Heidelberg, 69120 Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Im Neuenheimer Feld 410, Heidelberg</wicri:regionArea><placeName><region type="land" nuts="1">Bade-Wurtemberg</region><region type="district" nuts="2">District de Karlsruhe</region><settlement type="city">Heidelberg</settlement></placeName></affiliation></author><author><name sortKey="Drosten, Christian" sort="Drosten, Christian" uniqKey="Drosten C" first="Christian" last="Drosten">Christian Drosten</name><affiliation wicri:level="3"><nlm:aff id="Aff1"><institution-wrap><institution-id institution-id-type="GRID">grid.412102.4</institution-id><institution>Institute of Virology,</institution><institution>University of Bonn Medical Centre,</institution></institution-wrap>Sigmund-Freud-Strasse 25, Bonn, 53127 Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Sigmund-Freud-Strasse 25, Bonn</wicri:regionArea><placeName><region type="land" nuts="1">Rhénanie-du-Nord-Westphalie</region><region type="district" nuts="2">District de Cologne</region><settlement type="city">Bonn</settlement></placeName></affiliation></author></analytic><series><title level="j">Virology Journal</title><idno type="eISSN">1743-422X</idno><imprint><date when="2013">2013</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Acute Kidney Injury (virology)</term><term>Adult</term><term>Aged</term><term>Cells, Cultured</term><term>Coronavirus (physiology)</term><term>Coronavirus Infections (complications)</term><term>Epithelial Cells (virology)</term><term>Humans</term><term>Male</term><term>Middle Aged</term><term>Viral Tropism</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Adulte</term><term>Adulte d'âge moyen</term><term>Atteinte rénale aigüe (virologie)</term><term>Cellules cultivées</term><term>Cellules épithéliales (virologie)</term><term>Coronavirus (physiologie)</term><term>Humains</term><term>Infections à coronavirus ()</term><term>Mâle</term><term>Sujet âgé</term><term>Tropisme viral</term></keywords><keywords scheme="MESH" qualifier="complications" xml:lang="en"><term>Coronavirus Infections</term></keywords><keywords scheme="MESH" qualifier="physiologie" xml:lang="fr"><term>Coronavirus</term></keywords><keywords scheme="MESH" qualifier="physiology" xml:lang="en"><term>Coronavirus</term></keywords><keywords scheme="MESH" qualifier="virologie" xml:lang="fr"><term>Atteinte rénale aigüe</term><term>Cellules épithéliales</term></keywords><keywords scheme="MESH" qualifier="virology" xml:lang="en"><term>Acute Kidney Injury</term><term>Epithelial Cells</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Adult</term><term>Aged</term><term>Cells, Cultured</term><term>Humans</term><term>Male</term><term>Middle Aged</term><term>Viral Tropism</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Adulte</term><term>Adulte d'âge moyen</term><term>Cellules cultivées</term><term>Humains</term><term>Infections à coronavirus</term><term>Mâle</term><term>Sujet âgé</term><term>Tropisme viral</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><sec><title>Background</title><p>The Middle East Respiratory Syndrome Coronavirus (MERS-CoV) causes symptoms similar to Severe Acute Respiratory Syndrome Coronavirus (SARS-CoV), yet involving an additional component of acute renal failure (ARF) according to several published case reports. Impairment of the kidney is not typically seen in Coronavirus infections. The role of kidney infection in MERS is not understood.</p></sec><sec><title>Findings</title><p>A systematic review of communicated and peer-reviewed case reports revealed differences in descriptions of kidney involvement in MERS versus SARS patients. In particular, ARF in MERS patients occurred considerably earlier after a median time to onset of 11 days (SD ±2,0 days) as opposed to 20 days for SARS, according to the literature. <italic>In-situ</italic> histological staining of the respective cellular receptors for MERS- and SARS-Coronavirus showed highly similar staining patterns with a focus of a receptor-specific signal in kidney epithelial cells. Comparative infection experiments with SARS- and MERS-CoV in primary human kidney cells versus primary human bronchial epithelial cells showed cytopathogenic infection only in kidney cells, and only if infected with MERS-CoV. Kidney epithelial cells produced almost 1000-fold more infectious MERS-CoV progeny than bronchial epithelial cells, while only a small difference was seen between cell types when infected with SARS-CoV.</p></sec><sec><title>Conclusion</title><p>Epidemiological studies should analyze kidney impairment and its characteristics in MERS-CoV. Virus replication in the kidney with potential shedding in urine might constitute a way of transmission, and could explain untraceable transmission chains leading to new cases. Individual patients might benefit from early induction of renoprotective treatment.</p></sec><sec><title>Electronic supplementary material</title><p>The online version of this article (doi:10.1186/1743-422X-10-359) contains supplementary material, which is available to authorized users.</p></sec></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Peiris, Js" uniqKey="Peiris J">JS Peiris</name></author><author><name sortKey="Guan, Y" uniqKey="Guan Y">Y Guan</name></author><author><name sortKey="Yuen, Ky" uniqKey="Yuen K">KY Yuen</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Zaki, Am" uniqKey="Zaki A">AM Zaki</name></author><author><name sortKey="Van Boheemen, S" uniqKey="Van Boheemen S">S van Boheemen</name></author><author><name sortKey="Bestebroer, Tm" uniqKey="Bestebroer T">TM Bestebroer</name></author><author><name sortKey="Osterhaus, Ad" uniqKey="Osterhaus A">AD 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Rabeeah</name></author><author><name sortKey="Cummings, Da" uniqKey="Cummings D">DA Cummings</name></author><author><name sortKey="Alabdullatif, Zn" uniqKey="Alabdullatif Z">ZN Alabdullatif</name></author><author><name sortKey="Assad, M" uniqKey="Assad M">M Assad</name></author><author><name sortKey="Almulhim, A" uniqKey="Almulhim A">A Almulhim</name></author><author><name sortKey="Makhdoom, H" uniqKey="Makhdoom H">H Makhdoom</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Drosten, C" uniqKey="Drosten C">C Drosten</name></author><author><name sortKey="Seilmaier, M" uniqKey="Seilmaier M">M Seilmaier</name></author><author><name sortKey="Corman, Vm" uniqKey="Corman V">VM Corman</name></author><author><name sortKey="Hartmann, W" uniqKey="Hartmann W">W Hartmann</name></author><author><name sortKey="Scheible, G" uniqKey="Scheible G">G Scheible</name></author><author><name sortKey="Sack, S" uniqKey="Sack S">S Sack</name></author><author><name sortKey="Guggemos, W" uniqKey="Guggemos W">W Guggemos</name></author><author><name sortKey="Kallies, R" uniqKey="Kallies R">R Kallies</name></author><author><name sortKey="Muth, D" uniqKey="Muth D">D Muth</name></author><author><name sortKey="Junglen, S" uniqKey="Junglen S">S Junglen</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Guery, B" uniqKey="Guery B">B Guery</name></author><author><name sortKey="Poissy, J" uniqKey="Poissy J">J Poissy</name></author><author><name sortKey="El Mansouf, L" uniqKey="El Mansouf L">L el Mansouf</name></author><author><name sortKey="Sejourne, C" uniqKey="Sejourne C">C Sejourne</name></author><author><name sortKey="Ettahar, N" uniqKey="Ettahar N">N Ettahar</name></author><author><name sortKey="Lemaire, X" uniqKey="Lemaire X">X Lemaire</name></author><author><name sortKey="Vuotto, F" uniqKey="Vuotto F">F Vuotto</name></author><author><name sortKey="Goffard, A" uniqKey="Goffard A">A Goffard</name></author><author><name sortKey="Behillil, S" uniqKey="Behillil S">S Behillil</name></author><author><name sortKey="Enouf, V" uniqKey="Enouf V">V Enouf</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Pollack, Mp" uniqKey="Pollack M">MP Pollack</name></author><author><name sortKey="Pringle, C" uniqKey="Pringle C">C Pringle</name></author><author><name sortKey="Madoff, Lc" uniqKey="Madoff L">LC Madoff</name></author><author><name sortKey="Memish, Za" uniqKey="Memish Z">ZA Memish</name></author></analytic></biblStruct><biblStruct></biblStruct><biblStruct><analytic><author><name sortKey="Muller, Ma" uniqKey="Muller M">MA Muller</name></author><author><name sortKey="Raj, Vs" uniqKey="Raj V">VS Raj</name></author><author><name sortKey="Muth, D" uniqKey="Muth D">D Muth</name></author><author><name sortKey="Meyer, B" uniqKey="Meyer B">B Meyer</name></author><author><name sortKey="Kallies, S" uniqKey="Kallies S">S Kallies</name></author><author><name sortKey="Smits, Sl" uniqKey="Smits S">SL Smits</name></author><author><name sortKey="Wollny, R" uniqKey="Wollny R">R Wollny</name></author><author><name sortKey="Bestebroer, Tm" uniqKey="Bestebroer T">TM Bestebroer</name></author><author><name sortKey="Specht, S" uniqKey="Specht S">S Specht</name></author><author><name sortKey="Suliman, T" uniqKey="Suliman T">T Suliman</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Raj, Vs" uniqKey="Raj V">VS Raj</name></author><author><name sortKey="Mou, H" uniqKey="Mou H">H Mou</name></author><author><name sortKey="Smits, Sl" uniqKey="Smits S">SL Smits</name></author><author><name sortKey="Dekkers, Dh" uniqKey="Dekkers D">DH Dekkers</name></author><author><name sortKey="Muller, Ma" uniqKey="Muller M">MA Muller</name></author><author><name sortKey="Dijkman, R" uniqKey="Dijkman R">R Dijkman</name></author><author><name sortKey="Muth, D" uniqKey="Muth D">D Muth</name></author><author><name sortKey="Demmers, Ja" uniqKey="Demmers J">JA Demmers</name></author><author><name sortKey="Zaki, A" uniqKey="Zaki A">A Zaki</name></author><author><name sortKey="Fouchier, Ra" uniqKey="Fouchier R">RA Fouchier</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Hamming, I" uniqKey="Hamming I">I Hamming</name></author><author><name sortKey="Cooper, Me" uniqKey="Cooper M">ME Cooper</name></author><author><name sortKey="Haagmans, Bl" uniqKey="Haagmans B">BL Haagmans</name></author><author><name sortKey="Hooper, Nm" uniqKey="Hooper N">NM Hooper</name></author><author><name sortKey="Korstanje, R" uniqKey="Korstanje R">R Korstanje</name></author><author><name sortKey="Osterhaus, Ad" uniqKey="Osterhaus A">AD Osterhaus</name></author><author><name sortKey="Timens, W" uniqKey="Timens W">W Timens</name></author><author><name sortKey="Turner, Aj" uniqKey="Turner A">AJ Turner</name></author><author><name sortKey="Navis, G" uniqKey="Navis G">G Navis</name></author><author><name sortKey="Van Goor, H" uniqKey="Van Goor H">H van Goor</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Lambeir, Am" uniqKey="Lambeir A">AM Lambeir</name></author><author><name sortKey="Durinx, C" uniqKey="Durinx C">C Durinx</name></author><author><name sortKey="Scharpe, S" uniqKey="Scharpe S">S Scharpe</name></author><author><name sortKey="De Meester, I" uniqKey="De Meester I">I De Meester</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="De Groot, Rj" uniqKey="De Groot R">RJ de Groot</name></author><author><name sortKey="Baker, Sc" uniqKey="Baker S">SC Baker</name></author><author><name sortKey="Baric, Rs" uniqKey="Baric R">RS Baric</name></author><author><name sortKey="Brown, Cs" uniqKey="Brown C">CS Brown</name></author><author><name sortKey="Drosten, C" uniqKey="Drosten C">C Drosten</name></author><author><name sortKey="Enjuanes, L" uniqKey="Enjuanes L">L Enjuanes</name></author><author><name sortKey="Fouchier, Ra" uniqKey="Fouchier R">RA Fouchier</name></author><author><name sortKey="Galiano, M" uniqKey="Galiano M">M Galiano</name></author><author><name sortKey="Gorbalenya, Ae" uniqKey="Gorbalenya A">AE Gorbalenya</name></author><author><name sortKey="Memish, Za" uniqKey="Memish Z">ZA Memish</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Buchholz, U" uniqKey="Buchholz U">U Buchholz</name></author><author><name sortKey="Muller, Ma" uniqKey="Muller M">MA Muller</name></author><author><name sortKey="Nitsche, A" uniqKey="Nitsche A">A Nitsche</name></author><author><name sortKey="Sanewski, A" uniqKey="Sanewski A">A Sanewski</name></author><author><name sortKey="Wevering, N" uniqKey="Wevering N">N Wevering</name></author><author><name sortKey="Bauer Balci, T" uniqKey="Bauer Balci T">T Bauer-Balci</name></author><author><name sortKey="Bonin, F" uniqKey="Bonin F">F Bonin</name></author><author><name sortKey="Drosten, C" uniqKey="Drosten C">C Drosten</name></author><author><name sortKey="Schweiger, B" uniqKey="Schweiger B">B Schweiger</name></author><author><name sortKey="Wolff, T" uniqKey="Wolff T">T Wolff</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Bermingham, A" uniqKey="Bermingham A">A Bermingham</name></author><author><name sortKey="Chand, Ma" uniqKey="Chand M">MA Chand</name></author><author><name sortKey="Brown, Cs" uniqKey="Brown C">CS Brown</name></author><author><name sortKey="Aarons, E" uniqKey="Aarons E">E Aarons</name></author><author><name sortKey="Tong, C" uniqKey="Tong C">C Tong</name></author><author><name sortKey="Langrish, C" uniqKey="Langrish C">C Langrish</name></author><author><name sortKey="Hoschler, K" uniqKey="Hoschler K">K Hoschler</name></author><author><name sortKey="Brown, K" uniqKey="Brown K">K Brown</name></author><author><name sortKey="Galiano, M" uniqKey="Galiano M">M Galiano</name></author><author><name sortKey="Myers, R" uniqKey="Myers R">R Myers</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Corman, Vm" uniqKey="Corman V">VM Corman</name></author><author><name sortKey="Eckerle, I" uniqKey="Eckerle I">I Eckerle</name></author><author><name sortKey="Bleicker, T" uniqKey="Bleicker T">T Bleicker</name></author><author><name sortKey="Zaki, A" uniqKey="Zaki A">A Zaki</name></author><author><name sortKey="Landt, O" uniqKey="Landt O">O Landt</name></author><author><name sortKey="Eschbach Bludau, M" uniqKey="Eschbach Bludau M">M Eschbach-Bludau</name></author><author><name sortKey="Van Boheemen, S" uniqKey="Van Boheemen S">S van Boheemen</name></author><author><name sortKey="Gopal, R" uniqKey="Gopal R">R Gopal</name></author><author><name sortKey="Ballhause, M" uniqKey="Ballhause M">M Ballhause</name></author><author><name sortKey="Bestebroer, Tm" uniqKey="Bestebroer T">TM Bestebroer</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Chu, Kh" uniqKey="Chu K">KH Chu</name></author><author><name sortKey="Tsang, Wk" uniqKey="Tsang W">WK Tsang</name></author><author><name sortKey="Tang, Cs" uniqKey="Tang C">CS Tang</name></author><author><name sortKey="Lam, Mf" uniqKey="Lam M">MF Lam</name></author><author><name sortKey="Lai, Fm" uniqKey="Lai F">FM Lai</name></author><author><name sortKey="To, Kf" uniqKey="To K">KF To</name></author><author><name sortKey="Fung, Ks" uniqKey="Fung K">KS Fung</name></author><author><name sortKey="Tang, Hl" uniqKey="Tang H">HL Tang</name></author><author><name sortKey="Yan, Ww" uniqKey="Yan W">WW Yan</name></author><author><name sortKey="Chan, Hw" uniqKey="Chan H">HW Chan</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Falzarano, D" uniqKey="Falzarano D">D Falzarano</name></author><author><name sortKey="De Wit, E" uniqKey="De Wit E">E de Wit</name></author><author><name sortKey="Rasmussen, Al" uniqKey="Rasmussen A">AL Rasmussen</name></author><author><name sortKey="Feldmann, F" uniqKey="Feldmann F">F Feldmann</name></author><author><name sortKey="Okumura, A" uniqKey="Okumura A">A Okumura</name></author><author><name sortKey="Scott, Dp" uniqKey="Scott D">DP Scott</name></author><author><name sortKey="Brining, D" uniqKey="Brining D">D Brining</name></author><author><name sortKey="Bushmaker, T" uniqKey="Bushmaker T">T Bushmaker</name></author><author><name sortKey="Martellaro, C" uniqKey="Martellaro C">C Martellaro</name></author><author><name sortKey="Baseler, L" uniqKey="Baseler L">L Baseler</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Munster, Vj" uniqKey="Munster V">VJ Munster</name></author><author><name sortKey="De Wit, E" uniqKey="De Wit E">E de Wit</name></author><author><name sortKey="Feldmann, H" uniqKey="Feldmann H">H Feldmann</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="De Wit, E" uniqKey="De Wit E">E de Wit</name></author><author><name sortKey="Rasmussen, Al" uniqKey="Rasmussen A">AL Rasmussen</name></author><author><name sortKey="Falzarano, D" uniqKey="Falzarano D">D Falzarano</name></author><author><name sortKey="Bushmaker, T" uniqKey="Bushmaker T">T Bushmaker</name></author><author><name sortKey="Feldmann, F" uniqKey="Feldmann F">F Feldmann</name></author><author><name sortKey="Brining, Dl" uniqKey="Brining D">DL Brining</name></author><author><name sortKey="Fischer, Er" uniqKey="Fischer E">ER Fischer</name></author><author><name sortKey="Martellaro, C" uniqKey="Martellaro C">C Martellaro</name></author><author><name sortKey="Okumura, A" uniqKey="Okumura A">A Okumura</name></author><author><name sortKey="Chang, J" uniqKey="Chang J">J Chang</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Tang, Jw" uniqKey="Tang J">JW Tang</name></author><author><name sortKey="To, Kf" uniqKey="To K">KF To</name></author><author><name sortKey="Lo, Aw" uniqKey="Lo A">AW Lo</name></author><author><name sortKey="Sung, Jj" uniqKey="Sung J">JJ Sung</name></author><author><name sortKey="Ng, Hk" uniqKey="Ng H">HK Ng</name></author><author><name sortKey="Chan, Pk" uniqKey="Chan P">PK Chan</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Pacciarini, F" uniqKey="Pacciarini F">F Pacciarini</name></author><author><name sortKey="Ghezzi, S" uniqKey="Ghezzi S">S Ghezzi</name></author><author><name sortKey="Canducci, F" uniqKey="Canducci F">F Canducci</name></author><author><name sortKey="Sims, A" uniqKey="Sims A">A Sims</name></author><author><name sortKey="Sampaolo, M" uniqKey="Sampaolo M">M Sampaolo</name></author><author><name sortKey="Ferioli, E" uniqKey="Ferioli E">E Ferioli</name></author><author><name sortKey="Clementi, M" uniqKey="Clementi M">M Clementi</name></author><author><name sortKey="Poli, G" uniqKey="Poli G">G Poli</name></author><author><name sortKey="Conaldi, Pg" uniqKey="Conaldi P">PG Conaldi</name></author><author><name sortKey="Baric, R" uniqKey="Baric R">R Baric</name></author><author><name sortKey="Vicenzi, E" uniqKey="Vicenzi E">E Vicenzi</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Niemeyer, D" uniqKey="Niemeyer D">D Niemeyer</name></author><author><name sortKey="Zillinger, T" uniqKey="Zillinger T">T Zillinger</name></author><author><name sortKey="Muth, D" uniqKey="Muth D">D Muth</name></author><author><name sortKey="Zielecki, F" uniqKey="Zielecki F">F Zielecki</name></author><author><name sortKey="Horvath, G" uniqKey="Horvath G">G Horvath</name></author><author><name sortKey="Suliman, T" uniqKey="Suliman T">T Suliman</name></author><author><name sortKey="Barchet, W" uniqKey="Barchet W">W Barchet</name></author><author><name sortKey="Weber, F" uniqKey="Weber F">F Weber</name></author><author><name sortKey="Drosten, C" uniqKey="Drosten C">C Drosten</name></author><author><name sortKey="Muller, Ma" uniqKey="Muller M">MA Muller</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Goh, Gk" uniqKey="Goh G">GK Goh</name></author><author><name sortKey="Dunker, Ak" uniqKey="Dunker A">AK Dunker</name></author><author><name sortKey="Uversky, V" uniqKey="Uversky V">V Uversky</name></author></analytic></biblStruct></listBibl></div1></back></TEI><affiliations><list><country><li>Allemagne</li></country><region><li>Bade-Wurtemberg</li><li>District de Cologne</li><li>District de Karlsruhe</li><li>Rhénanie-du-Nord-Westphalie</li></region><settlement><li>Bonn</li><li>Heidelberg</li></settlement></list><tree><country name="Allemagne"><region name="Rhénanie-du-Nord-Westphalie"><name sortKey="Eckerle, Isabella" sort="Eckerle, Isabella" uniqKey="Eckerle I" first="Isabella" last="Eckerle">Isabella Eckerle</name></region><name sortKey="Drosten, Christian" sort="Drosten, Christian" uniqKey="Drosten C" first="Christian" last="Drosten">Christian Drosten</name><name sortKey="Gotthardt, Daniel N" sort="Gotthardt, Daniel N" uniqKey="Gotthardt D" first="Daniel N" last="Gotthardt">Daniel N. Gotthardt</name><name sortKey="Kallies, Stephan" sort="Kallies, Stephan" uniqKey="Kallies S" first="Stephan" last="Kallies">Stephan Kallies</name><name sortKey="Muller, Marcel A" sort="Muller, Marcel A" uniqKey="Muller M" first="Marcel A" last="Müller">Marcel A. Müller</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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